Animal and human studies that we have conducted aiming to understand clinical benefits and toxicity of tocotrienol:

1. Acute Dermal Toxicity Study in Rats
2. Acute Oral Toxicity Study in Rats
3. Primary Eye Irritation Study in Rabbits
4. Salmonella Typhimurium And Escherichia Coli Reverse Mutation Assay
5. Acute toxicity to Daphnia magna in a 48 hour immobilization test
6. Acute Toxicity to Zebra Fish (Brachydanio rerio) in a 96-Hour Semi-Static Test
7. Toxicity to Pseudokirchneriella subcapitata (Formerly Selenastrum capricornutum) in a 72-Hour Algal Growth Inhibition Test
8. Ready Biodegradability in a Manometric Respirometry Test
9. Evaluation of the Skin Tolerance of Different Cosmetic Preparations by Means of a Single Occluded Application (Single Insult Patch Test)
10. Evaluation of The Skin Tolerance of Different Cosmetic Preparations By Means of A Repeated Occluded Application (4 x Repeated Insult Patch Test)
11. Evaluation of The Moisturizing and Skin Barrier Supporting Properties of Different Cosmetic Products
12. Effect Of Compounds On the Migration of Human Fibroblasts and Human Keratinocytes
13. Determination of the Radical Hair Protection Factor (RHF) of Tocopherol/Tocotrienol Derivatives
14. Determination of the Radical Skin/Sun Protection Factor (RSF) of Tocopherol/Tocotrienol Derivatives
15. Determination of the Skin Antioxidative Protection (SAP) of Tocopherol/Tocotrienol Derivatives
16. UV-Irritation Model Conducted With Six Test Products against A Positive Control
17. Yap YL. "Evidence of Gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing and chemotherapy drug-sensitizing agent in human cancer cells", US provisional application filed on October 23, 2008.
18. Chang PN, Yap WN, DTW Lee, Ling MT, Wong YC, Yap YL. "Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing and chemotherapy drug-sensitizing agent in human melanoma cells", Nutrition and Cancer: An International Journal 2009 May;61(3)
19. Yap WN, Chang PN, HY Han, Lee DTW Ling MT, Wong YC, Yap YL. "Gamma-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple signaling pathways", Br J Cancer. 2008 Nov 11. 
20. Chen L, Yap YL. “Automated charge state determination of complex isotope-resolved mass spectra by peak-target Fourier transform” , J Am Soc Mass Spectrom. 2008 Jan;19(1):46-54.
21. Zhang X, Yap Y, Wei D, Chen G, Chen F. “Novel omics technologies in nutrition research” , Biotechnol Adv. 2008 Mar-Apr;26(2):169-76. Epub 2007 Nov 19.
22. Yap YL, Zhang XW, Smith D, Soong R, Hill J. “Molecular gene expression signature patterns for gastric cancer diagnosis” , Comput Biol Chem. 2007 Aug;31(4):275-87.
23. Yap DY, Smith DK, Zhang XW, Hill J. “Using biomarker signature patterns for an mRNA molecular diagnostic of mouse embryonic stem cell differentiation state” BMC Genomics. 2007 Jul 3;8:210.
24. Zhang XW, Yap YL, Wei D, Chen F, Danchin A. “Molecular diagnosis of human cancer type by gene expression profiles and independent component analysis” Eur J Hum Genet. 2005 Dec;13(12):1303-11.
25. Yap YL, Lam DC, Luc G, Zhang XW, Hernandez D, Gras R, Wang E, Chiu SW, Chung LP, Lam WK, Smith DK, Minna JD, Danchin A, Wong MP. “Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays” Nucleic Acids Res. 2005 Jan 14;33(1):409-21.
26. Yap Y, Zhang X, Ling MT, Wang X, Wong YC, Danchin A. “Classification between normal and tumor tissues based on the pair-wise gene expression ratio”  BMC Cancer. 2004 Oct 7;4:72