DavosLife's R&D team has unraveled multiple molecular pathways responsible for tocotrienol’s anti-cancer properties. In particular, we elucidated for the first time how tocotrienol can target prostate cancer stem cells that are not affected by docetaxel, a common chemotherapy agent. We have conducted animal and human studies aimed at understanding the clinical benefits, safety and tolerability of tocotrienol. The experimental results generated indicated that besides its anti-cancer properties, tocotrienol has cholesterol and triglyceride lowering potential with low toxicity in humans. Results from studies conducted in human skin models have shown that tocotrienol-rich formulations possess photo-protective and skin depigmentation effects in addition to its reparative and skin hydration properties. Our high quality of research was recognized by Frost & Sullivan in 2010 for “Asia Pacific Excellence in Research Award for Natural Vitamin E market”.
DavosLife has conducted several in vivo and in vitro studies utilizing Naturale3 on three major therapy areas:
1. Tocotrienol in cancer prevention and therapy
2. Tocotrienol in cardiovascular and metabolic health
3. Tocotrienol in skincare & cosmetics
DavosLife’s published research includes topics on the following areas:
- Cancer: Tocotrienols, besides killing normal cancer cells, could also kill prostate cancer stem cells that are unaffected by Docetaxel, a common chemotherapy drug. Cancer stem cells are believed to be responsible for cancer initiation and recurrence. DavosLife research showed that the development of prostate cancer tumours was prevented in mice pre-treated with gamma-tocotrienol through a stem cell-targeting mechanism. This suggests that gamma-tocotrienol has the potential to be used for prostate cancer prevention and treatment.
- Metabolic Syndrome: Gamma- and delta-tocotrienols were found to lower triglyceride formation and transportation. Triglycerides are a form of fat, and high levels are associated with increased risk of cardiovascular and metabolic diseases. In a study by DavosLife, tocotrienols were shown to reduce the production and transport of triglyceride by 28% after 8 weeks of twice daily supplementation.
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- Skin Depigmentation: Our research showed tocotrienol is able to promote skin depigmentation through inhibition of the key protein tyrosinase in melanin synthesis. DavosLife’s research revealed that tocotrienols reduced melanin production by up to 55% via inhibition of tyrosinase enzyme activity at a concentration 150 times lower than other skin depigmentation agents.